Tomo Kurobe Research Website

Medaka Toxicity Testing

We are using medaka as a model for assessment of endocrine disruption because of the following advantages:

  1. Medaka is a small fish, easy to breed and maintain in large numbers under laboratory conditions, has high growth rates and matures from fry to breeding adults in a relatively short period (8-10 weeks).
  2. Medaka is a gonochoristic fish species and has the XY-XX genetic sex determination system, while zebrefish being the most studied model fish species is hermaphroditic until the juvenile stage and all individuals develop ovary-like gonad. This feature allows us to evaluate sex specific effects of chemicals of emerging concerns.

Preliminary Results

Useful Links

  • Stages of normal development in the Medaka Oryzias latipes [MEPD: Medaka Expression Pattern Database]